Assay Detail
Binding
CHEMBL5514028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction by alpha screen assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.06 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519023 | — | — | 1 | 8.30 |
| CHEMBL1714813 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519023 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1714813 | — | IC50 | = | 1500.0 | nM | 5.82 |