Assay Detail
Binding
CHEMBL5514037
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Binding affinity to ENPP1 (unknown origin) assessed as inhibition constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.39 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.58 |
| CHEMBL4277262 | — | — | 1 | 5.25 |
| CHEMBL4285222 | — | — | 1 | 5.17 |
| CHEMBL5559294 | — | — | 1 | 5.05 |
| CHEMBL1206141 | — | — | 1 | 4.92 |
| CHEMBL3289396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL4277262 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL4285222 | — | Ki | = | 6820.0 | nM | 5.17 |
| CHEMBL5559294 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1206141 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3289396 | — | Ki | = | 20000.0 | nM | - |