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Assay Detail

CHEMBL5514746

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate measured after 20 mins by spectrophotometer
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Alpha-glucosidase (CHEMBL5291954)
Type PROTEIN FAMILY
Organism Saccharomyces cerevisiae S288c

Publication

Evaluation of novel 2-(quinoline-2-ylthio)acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo studies on their anti-diabetic properties.
Khalili Ghomi M, Noori M, Mirahmad M, Iraji A, Sadr AS, Dastyafteh N, Asili P, Gholami M, Javanshir S, Lotfi M, Mojtabavi S, Faramarzi MA, Asadi M, Nasli-Esfahani E, Palimi M, Larijani B, Meshkatalsadat MH, Mahdavi M.
Eur J Med Chem (2024) 269 : 116332 -116332
PubMed 38508120 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.86 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5561939 1 6.75
CHEMBL5564862 1 6.02
CHEMBL5564791 1 5.99
CHEMBL5566089 1 5.91
CHEMBL5542429 1 5.91
CHEMBL5565799 1 5.90
CHEMBL5559636 1 5.90
CHEMBL5566891 1 5.83
CHEMBL5561807 1 5.82
CHEMBL5561137 1 5.82
CHEMBL5564154 1 5.80
CHEMBL5562381 1 5.75
CHEMBL5561618 1 5.75
CHEMBL5532121 1 5.75
CHEMBL5568014 1 5.73
CHEMBL5563122 1 5.71
CHEMBL5566920 1 5.70
CHEMBL5560964 1 5.70
CHEMBL5555386 1 5.69
CHEMBL5567811 1 5.68
CHEMBL404271 ACARBOSE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5561939 IC50 = 180.0 nM 6.75
CHEMBL5564862 IC50 = 960.0 nM 6.02
CHEMBL5564791 IC50 = 1020.0 nM 5.99
CHEMBL5566089 IC50 = 1240.0 nM 5.91
CHEMBL5542429 IC50 = 1220.0 nM 5.91
CHEMBL5565799 IC50 = 1260.0 nM 5.90
CHEMBL5559636 IC50 = 1250.0 nM 5.90
CHEMBL5566891 IC50 = 1480.0 nM 5.83
CHEMBL5561807 IC50 = 1530.0 nM 5.82
CHEMBL5561137 IC50 = 1500.0 nM 5.82
CHEMBL5564154 IC50 = 1580.0 nM 5.80
CHEMBL5562381 IC50 = 1800.0 nM 5.75
CHEMBL5561618 IC50 = 1770.0 nM 5.75
CHEMBL5532121 IC50 = 1790.0 nM 5.75
CHEMBL5568014 IC50 = 1850.0 nM 5.73
CHEMBL5563122 IC50 = 1950.0 nM 5.71
CHEMBL5566920 IC50 = 2020.0 nM 5.70
CHEMBL5560964 IC50 = 1980.0 nM 5.70
CHEMBL5555386 IC50 = 2050.0 nM 5.69
CHEMBL5567811 IC50 = 2100.0 nM 5.68
CHEMBL404271 ACARBOSE IC50 = 750200.0 nM -