Assay Detail
Binding
CHEMBL5514748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Saccharomyces cerevisiae alpha-glucosidase using varying concentrations of p-nitrophenyl-alpha-D-glucopyranoside as substrate by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Alpha-glucosidase (CHEMBL5291954) ↗| Type | PROTEIN FAMILY |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Evaluation of novel 2-(quinoline-2-ylthio)acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo studies on their anti-diabetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.06 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561939 | — | — | 1 | 6.82 |
| CHEMBL5566089 | — | — | 1 | 5.92 |
| CHEMBL5565799 | — | — | 1 | 5.85 |
| CHEMBL5542429 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561939 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5566089 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL5565799 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL5542429 | — | Ki | = | 2200.0 | nM | 5.66 |