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Assay Detail

CHEMBL5515086

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of NF-kappaB (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Nuclear factor NF-kappa-B complex (CHEMBL2094258)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Drug development and potential targets for Cushing's syndrome.
Wei W, Xu Q, Wu L, Gong G, Tian Y, Huang H, Li Z.
Eur J Med Chem (2024) 270 : 116333 -116333
PubMed 38569434 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 6.73 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL463763 TRIPTOLIDE 3.0 1 8.00
CHEMBL2348780 VAMOROLONE 4.0 1 7.18
CHEMBL421 SULFASALAZINE 4.0 1 5.00
CHEMBL325041 BORTEZOMIB 3.0 1 -
CHEMBL140 CURCUMIN 3.0 1 -
CHEMBL154111 SALSALATE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL463763 TRIPTOLIDE IC50 = 10.0 nM 8.00
CHEMBL2348780 VAMOROLONE IC50 = 65.9 nM 7.18
CHEMBL421 SULFASALAZINE IC50 = 10000.0 nM 5.00
CHEMBL325041 BORTEZOMIB IC50 <= 10.0 nM -
CHEMBL140 CURCUMIN IC50 <= 1000.0 nM -
CHEMBL154111 SALSALATE IC50 <= 2000.0 nM -