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Compound Detail

CHEMBL154111

SALSALATE
🧪 Phase II
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🧪 Phase II
O=C(Oc1ccccc1C(=O)O)c1ccccc1O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL154111
Name SALSALATE
Phase Phase II
Structure Type MOL
InChI Key WVYADZUPLLSGPU-UHFFFAOYSA-N
Therapeutic ✓ Yes
Active Moiety CHEMBL424

Known Names

Disalcid Disalicyclic acid NSC-49171 Salicylic acid, bimolecular ester Salicylsalicylic acid Salsalate Salsalato Sasapyrine
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
8
Known Names
15
Indications

Molecular Properties

258.2
MW (Da)
2.31
ALogP
4
HBA
2
HBD
83.8
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product Prodrug
USAN Stem sal-; -sal-
USAN Year 1972

Extended Properties

Molecular Formula C14H10O5
MW 258.23
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -0.10

Indications

Fever Pain Anemia Atherosclerosis Diabetes Mellitus, Type 2 Metabolic Syndrome Obesity Polycystic Ovary Syndrome Alzheimer Disease Diabetes Mellitus Diabetic Neuropathies Insulin Resistance Supranuclear Palsy, Progressive Endometriosis Pre-Eclampsia

ATC Classification

N02BA06
salsalate
Level 1: NERVOUS SYSTEM
Level 2: ANALGESICS

Drug Warnings

Black Box Warning
neurotoxicity
Country: United States
Black Box Warning
cardiotoxicity
Country: United States
Black Box Warning
gastrointestinal toxicity
Country: United States

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
26048786 10.1016/j.bmcl.2015.04.077 Mus musculus 3
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
38569434 10.1016/j.ejmech.2024.116333 Nuclear factor NF-kappa-B complex 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
20020916 10.1080/15376510701857262 Phospholipidosis 1

Data from ChEMBL 36 via Core Engine