Assay Detail
Binding
CHEMBL5515537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK5 (unknown origin) incubated for 2 hrs in presence of ATP by ADP-Glo reagent based luminescence plate reader analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.76 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557584 | — | — | 1 | 7.76 |
| CHEMBL5559089 | — | — | 1 | 7.32 |
| CHEMBL2364611 | GALUNISERTIB | 2.0 | 1 | 7.30 |
| CHEMBL5527856 | — | — | 1 | 7.19 |
| CHEMBL5555142 | — | — | 1 | 7.17 |
| CHEMBL5561604 | — | — | 1 | 7.10 |
| CHEMBL5561885 | — | — | 1 | 7.04 |
| CHEMBL5566771 | — | — | 1 | 6.88 |
| CHEMBL5558203 | — | — | 1 | 6.86 |
| CHEMBL5560338 | — | — | 1 | 6.81 |
| CHEMBL5559812 | — | — | 1 | 6.75 |
| CHEMBL5561312 | — | — | 1 | 6.74 |
| CHEMBL5561520 | — | — | 1 | 6.58 |
| CHEMBL5566758 | — | — | 1 | 6.57 |
| CHEMBL5568115 | — | — | 1 | 6.56 |
| CHEMBL5557295 | — | — | 1 | 6.51 |
| CHEMBL5564485 | — | — | 1 | 6.41 |
| CHEMBL5542740 | — | — | 1 | 6.39 |
| CHEMBL5556705 | — | — | 1 | 6.28 |
| CHEMBL5558732 | — | — | 1 | 6.22 |
| CHEMBL5566210 | — | — | 1 | 6.19 |
| CHEMBL5559953 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557584 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5559089 | — | IC50 | = | 48.3 | nM | 7.32 |
| CHEMBL2364611 | GALUNISERTIB | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL5527856 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL5555142 | — | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL5561604 | — | IC50 | = | 80.2 | nM | 7.10 |
| CHEMBL5561885 | — | IC50 | = | 91.3 | nM | 7.04 |
| CHEMBL5566771 | — | IC50 | = | 132.6 | nM | 6.88 |
| CHEMBL5558203 | — | IC50 | = | 137.9 | nM | 6.86 |
| CHEMBL5560338 | — | IC50 | = | 155.1 | nM | 6.81 |
| CHEMBL5559812 | — | IC50 | = | 176.3 | nM | 6.75 |
| CHEMBL5561312 | — | IC50 | = | 181.8 | nM | 6.74 |
| CHEMBL5561520 | — | IC50 | = | 262.3 | nM | 6.58 |
| CHEMBL5566758 | — | IC50 | = | 270.5 | nM | 6.57 |
| CHEMBL5568115 | — | IC50 | = | 273.5 | nM | 6.56 |
| CHEMBL5557295 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5564485 | — | IC50 | = | 386.4 | nM | 6.41 |
| CHEMBL5542740 | — | IC50 | = | 407.9 | nM | 6.39 |
| CHEMBL5556705 | — | IC50 | = | 521.3 | nM | 6.28 |
| CHEMBL5558732 | — | IC50 | = | 596.7 | nM | 6.22 |
| CHEMBL5566210 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL5559953 | — | IC50 | = | 873.5 | nM | 6.06 |