Compound Detail
CHEMBL5566771
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Basic Information
| ChEMBL ID | CHEMBL5566771 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PRZUEMDYNWMBKC-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
465.6
MW (Da)
4.50
ALogP
6
HBA
2
HBD
105.7
PSA (Ų)
0.40
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.56
IC50 1 meas. best 6.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 6.88 | 6.88 | 132.6 | 1 |
| TGF-beta receptor type-1 CHEMBL2021750 | EC50 | 6.56 | 6.56 | 273.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | IC50 | = | 132.6 | nM | 6.88 | Inhibition of ALK5 (unknown origin) incubated for 2 hrs in presence of ATP by AD... | 38626523 |
| TGF-beta receptor type-1 | EC50 | = | 273.2 | nM | 6.56 | Inhibition of ALK5 signaling in mouse NIH3T3 cells transfected with (CAGA)12-luc... | 38626523 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38626523 | 10.1016/j.ejmech.2024.116395 | TGF-beta receptor type-1 | 2 |
Data from ChEMBL 36 via Core Engine