Assay Detail
Functional
CHEMBL5516144
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Antioxidant activity assessed as inhibition of peroxynitrite mediated L-tyrosine nitration in sodium phosphate buffer at pH 7.5 incubated for 7 mins by RP-HPLC analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selenization of Small Molecule Drugs: A New Player on the Board.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.50 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555319 | — | — | 1 | 5.11 |
| CHEMBL5517779 | — | — | 1 | 4.91 |
| CHEMBL1515 | METHIMAZOLE | 4.0 | 1 | 4.62 |
| CHEMBL5560226 | — | — | 1 | 4.38 |
| CHEMBL5557885 | — | — | 1 | 4.31 |
| CHEMBL1330588 | METHYLTHIOURACIL | 2.0 | 1 | 4.18 |
| CHEMBL1518 | PROPYLTHIOURACIL | 4.0 | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555319 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5517779 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL1515 | METHIMAZOLE | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL5560226 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL5557885 | — | IC50 | = | 49100.0 | nM | 4.31 |
| CHEMBL1330588 | METHYLTHIOURACIL | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL1518 | PROPYLTHIOURACIL | IC50 | = | 95000.0 | nM | 4.02 |