Assay Detail
Binding
CHEMBL5516149
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Inhibition of LPO (unknown origin)-mediated L-tyrosine nitration incubated for 20 mins in presence of H2O2 and sodium nitrite by RP-HPLC analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selenization of Small Molecule Drugs: A New Player on the Board.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.40 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1515 | METHIMAZOLE | 4.0 | 1 | 6.29 |
| CHEMBL5517779 | — | — | 1 | 6.23 |
| CHEMBL1330588 | METHYLTHIOURACIL | 2.0 | 1 | 5.83 |
| CHEMBL5555319 | — | — | 1 | 5.66 |
| CHEMBL5560226 | — | — | 1 | 5.26 |
| CHEMBL5557885 | — | — | 1 | 5.14 |
| CHEMBL1518 | PROPYLTHIOURACIL | 4.0 | 1 | 5.12 |
| CHEMBL5557030 | — | — | 1 | 4.64 |
| CHEMBL5558431 | — | — | 1 | 4.41 |
| CHEMBL5561937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1515 | METHIMAZOLE | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5517779 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1330588 | METHYLTHIOURACIL | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5555319 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5560226 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5557885 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1518 | PROPYLTHIOURACIL | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL5557030 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL5558431 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL5561937 | — | IC50 | = | 137000.0 | nM | - |