Assay Detail
Binding
CHEMBL5516201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human cathepsin S using Z-Phe-Arg-AMC as substrate incubated for 60 mins
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.96 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566531 | — | — | 1 | 8.45 |
| CHEMBL5558707 | — | — | 1 | 8.34 |
| CHEMBL5564971 | — | — | 1 | 8.10 |
| CHEMBL5561728 | — | — | 1 | 8.10 |
| CHEMBL5549898 | — | — | 1 | 7.65 |
| CHEMBL5568269 | — | — | 1 | 7.65 |
| CHEMBL5559134 | — | — | 1 | 7.64 |
| CHEMBL5565472 | — | — | 1 | 7.63 |
| CHEMBL5559003 | — | — | 1 | 7.54 |
| CHEMBL5562042 | — | — | 1 | 7.25 |
| CHEMBL5556766 | — | — | 1 | 6.75 |
| CHEMBL5559068 | — | — | 1 | 6.33 |
| CHEMBL5559371 | — | — | 1 | 6.18 |
| CHEMBL5562393 | — | — | 1 | 6.12 |
| CHEMBL5558496 | — | — | 1 | 5.98 |
| CHEMBL5560182 | — | — | 1 | 5.74 |
| CHEMBL5557407 | — | — | 1 | 5.73 |
| CHEMBL5560304 | — | — | 1 | 5.59 |
| CHEMBL5532074 | — | — | 1 | 5.52 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | - |
| CHEMBL5564222 | — | — | 1 | - |
| CHEMBL5568382 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566531 | — | Ki | = | 3.56 | nM | 8.45 |
| CHEMBL5558707 | — | Ki | = | 4.59 | nM | 8.34 |
| CHEMBL5564971 | — | Ki | = | 8.01 | nM | 8.10 |
| CHEMBL5561728 | — | Ki | = | 7.93 | nM | 8.10 |
| CHEMBL5549898 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL5568269 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL5559134 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL5565472 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL5559003 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5562042 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL5556766 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL5559068 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL5559371 | — | Ki | = | 662.0 | nM | 6.18 |
| CHEMBL5562393 | — | Ki | = | 765.0 | nM | 6.12 |
| CHEMBL5558496 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL5560182 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL5557407 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL5560304 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL5532074 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL4802135 | NIRMATRELVIR | Ki | - | — | - | |
| CHEMBL5564222 | — | Ki | - | — | - | |
| CHEMBL5568382 | — | Ki | - | — | - |