Assay Detail
Binding
CHEMBL5516901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by thallium flux assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-REX-CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-sensitive inward rectifier potassium channel 1 (CHEMBL1293292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557617 | — | — | 1 | 9.00 |
| CHEMBL5560084 | — | — | 1 | 8.18 |
| CHEMBL5560628 | — | — | 1 | 8.06 |
| CHEMBL5558589 | — | — | 1 | 7.89 |
| CHEMBL5561980 | — | — | 1 | 7.89 |
| CHEMBL5559136 | — | — | 1 | 7.85 |
| CHEMBL5560081 | — | — | 1 | 7.82 |
| CHEMBL5562228 | — | — | 1 | 7.82 |
| CHEMBL5560640 | — | — | 1 | 7.82 |
| CHEMBL5557656 | — | — | 1 | 7.80 |
| CHEMBL5523625 | — | — | 1 | 7.77 |
| CHEMBL5565705 | — | — | 1 | 7.77 |
| CHEMBL5560085 | — | — | 1 | 7.64 |
| CHEMBL5563848 | — | — | 1 | 7.62 |
| CHEMBL5560684 | — | — | 1 | 7.60 |
| CHEMBL5561669 | — | — | 1 | 7.58 |
| CHEMBL5560876 | — | — | 1 | 7.52 |
| CHEMBL5556159 | — | — | 1 | 7.50 |
| CHEMBL5563632 | — | — | 1 | 7.44 |
| CHEMBL5560041 | — | — | 1 | 7.34 |
| CHEMBL5556822 | — | — | 1 | 7.28 |
| CHEMBL5555211 | — | — | 1 | 7.24 |
| CHEMBL5560486 | — | — | 1 | 7.23 |
| CHEMBL5558564 | — | — | 1 | 7.21 |
| CHEMBL5517758 | — | — | 1 | 7.21 |
| CHEMBL5549890 | — | — | 1 | 7.13 |
| CHEMBL5555792 | — | — | 1 | 7.08 |
| CHEMBL5527997 | — | — | 1 | 7.07 |
| CHEMBL5523626 | — | — | 1 | 6.37 |
| CHEMBL5556245 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557617 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5560084 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5560628 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5558589 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5561980 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5559136 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5560081 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5562228 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5560640 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5557656 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5523625 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5565705 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5560085 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5563848 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5560684 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5561669 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5560876 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5556159 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5563632 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5560041 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5556822 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5555211 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5560486 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5558564 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5517758 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5549890 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5555792 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5527997 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5523626 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5556245 | — | IC50 | = | 620.0 | nM | 6.21 |