Compound Detail
CHEMBL5556245
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Basic Information
| ChEMBL ID | CHEMBL5556245 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LOFUMCJUAHZTJC-NRFANRHFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
2.53
ALogP
8
HBA
0
HBD
110.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 1 CHEMBL1293292 | IC50 | 6.21 | 6.21 | 620.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 1 | IC50 | = | 620.0 | nM | 6.21 | Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 30 mins by t... | 38807539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38807539 | 10.1021/acs.jmedchem.4c00893 | ATP-sensitive inward rectifier potassium channel 1 | 1 |
Data from ChEMBL 36 via Core Engine