Assay Detail

CHEMBL5516941

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Binding

Inhibition of BSEP (unknown origin)

ChEMBL ↗

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Target

Bile salt export pump (CHEMBL6020) ↗

Open DB target context

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Bile salt export pump (CHEMBL6020) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bile salt export pump

CHEMBL6020

Anchored from Assay target.

Protein identity Bile salt export pump

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Bile salt export pump (CHEMBL6020) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.

Richter JM, Gunaga P, Yadav N, Bora RO, Bhide R, Rajugowda N, Govindrajulu K, Godesi S, Akuthota N, Rao P, Sivaraman A, Panda M, Kaspady M, Gupta A, Mathur A, Levesque PC, Gulia J, Dokania M, Ramarao M, Kole P, Chacko S, Lentz KA, Sivaprasad Lvj S, Thatipamula RP, Sridhar S, Kamble S, Govindrajan A, Soleman SI, Gordon DA, Wexler RR, Priestley ES.
J Med Chem (2024) 67 : 9731 -9744
PubMed 38807539 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.16	5.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5563848	—	—	1	5.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5563848	—	IC50	=	7000.0	nM	5.16