Assay Detail
Binding
CHEMBL5518336
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Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins by spectrophotometric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Recent advances in triazoles as tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.04 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424468 | — | — | 1 | 8.00 |
| CHEMBL5563258 | — | — | 1 | 7.82 |
| CHEMBL5560484 | — | — | 1 | 7.30 |
| CHEMBL5559951 | — | — | 1 | 6.95 |
| CHEMBL5559662 | — | — | 1 | 6.91 |
| CHEMBL5566933 | — | — | 1 | 6.62 |
| CHEMBL5568234 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424468 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5563258 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5560484 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5559951 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5559662 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5566933 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5568234 | — | IC50 | = | 2010.0 | nM | 5.70 |