Assay Detail
Binding
CHEMBL5518337
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Inhibition of mushroom tyrosinase using L-DOPA as substrate pre-treated for 10 mins followed by substrate addition measured for 20 mins by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Recent advances in triazoles as tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555176 | — | — | 1 | 9.00 |
| CHEMBL5567981 | — | — | 1 | 8.70 |
| CHEMBL5542984 | — | — | 1 | 8.22 |
| CHEMBL5555631 | — | — | 1 | 8.22 |
| CHEMBL5563258 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555176 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5567981 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5542984 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5555631 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5563258 | — | IC50 | = | 16832.0 | nM | 4.77 |