Assay Detail
Binding
CHEMBL5518833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin) by ELISA analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.53 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560855 | — | — | 1 | 8.85 |
| CHEMBL5560277 | — | — | 1 | 8.85 |
| CHEMBL5558820 | — | — | 1 | 8.77 |
| CHEMBL5564873 | — | — | 1 | 8.72 |
| CHEMBL5560892 | — | — | 1 | 8.49 |
| CHEMBL5542547 | — | — | 1 | 8.49 |
| CHEMBL5560263 | — | — | 1 | 8.28 |
| CHEMBL5557504 | — | — | 1 | 8.25 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 8.07 |
| CHEMBL4871361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560855 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5560277 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5558820 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5564873 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5560892 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5542547 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5560263 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5557504 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4871361 | — | IC50 | < | 0.2 | nM | - |