Assay Detail
Binding
CHEMBL5519283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PELI1 FHA domain (unknown origin) expressed in Escherichia coli BL21(DE3) competent cell measured after 1 min by fluorescence quenching assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
E3 ubiquitin-protein ligase pellino homolog 1 (CHEMBL6066217) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Resveratrol-derived inhibitors of the E3 ubiquitin ligase PELI1 inhibit the metastasis of triple-negative breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 54 | 4.53 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560298 | — | — | 1 | 5.28 |
| CHEMBL5542921 | — | — | 1 | 5.24 |
| CHEMBL5566406 | — | — | 1 | 5.15 |
| CHEMBL5412968 | — | — | 1 | 5.09 |
| CHEMBL5562660 | — | — | 1 | 4.94 |
| CHEMBL5559040 | — | — | 1 | 4.92 |
| CHEMBL5410440 | — | — | 1 | 4.87 |
| CHEMBL5440044 | — | — | 1 | 4.82 |
| CHEMBL5432112 | — | — | 1 | 4.71 |
| CHEMBL5435393 | — | — | 1 | 4.65 |
| CHEMBL5417329 | — | — | 1 | 4.58 |
| CHEMBL5418959 | — | — | 1 | 4.57 |
| CHEMBL5403221 | — | — | 1 | 4.42 |
| CHEMBL5560896 | — | — | 1 | 4.41 |
| CHEMBL5558789 | — | — | 1 | 4.40 |
| CHEMBL5415636 | — | — | 1 | 4.37 |
| CHEMBL5404281 | — | — | 1 | 4.37 |
| CHEMBL5424509 | — | — | 1 | 4.35 |
| CHEMBL5557659 | — | — | 1 | 4.29 |
| CHEMBL5395090 | — | — | 1 | 4.28 |
| CHEMBL5401135 | — | — | 1 | 4.25 |
| CHEMBL5395132 | — | — | 1 | 4.22 |
| CHEMBL5428405 | — | — | 1 | 4.19 |
| CHEMBL5567921 | — | — | 1 | 4.15 |
| CHEMBL5557050 | — | — | 1 | 4.09 |
| CHEMBL5557824 | — | — | 1 | 4.06 |
| CHEMBL5398839 | — | — | 1 | 4.05 |
| CHEMBL5560444 | — | — | 1 | 4.02 |
| CHEMBL5398320 | — | — | 1 | - |
| CHEMBL5437018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560298 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL5542921 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL5566406 | — | Kd | = | 7100.0 | nM | 5.15 |
| CHEMBL5412968 | — | Kd | = | 8200.0 | nM | 5.09 |
| CHEMBL5562660 | — | Kd | = | 11400.0 | nM | 4.94 |
| CHEMBL5559040 | — | Kd | = | 11900.0 | nM | 4.92 |
| CHEMBL5410440 | — | Kd | = | 13620.0 | nM | 4.87 |
| CHEMBL5440044 | — | Kd | = | 15300.0 | nM | 4.82 |
| CHEMBL5432112 | — | Kd | = | 19720.0 | nM | 4.71 |
| CHEMBL5435393 | — | Kd | = | 22600.0 | nM | 4.65 |
| CHEMBL5417329 | — | Kd | = | 26300.0 | nM | 4.58 |
| CHEMBL5418959 | — | Kd | = | 26900.0 | nM | 4.57 |
| CHEMBL5403221 | — | Kd | = | 37900.0 | nM | 4.42 |
| CHEMBL5560896 | — | Kd | = | 39300.0 | nM | 4.41 |
| CHEMBL5558789 | — | Kd | = | 40100.0 | nM | 4.40 |
| CHEMBL5415636 | — | Kd | = | 43200.0 | nM | 4.37 |
| CHEMBL5404281 | — | Kd | = | 42300.0 | nM | 4.37 |
| CHEMBL5424509 | — | Kd | = | 44400.0 | nM | 4.35 |
| CHEMBL5557659 | — | Kd | = | 51500.0 | nM | 4.29 |
| CHEMBL5395090 | — | Kd | = | 52180.0 | nM | 4.28 |
| CHEMBL5401135 | — | Kd | = | 55700.0 | nM | 4.25 |
| CHEMBL5395132 | — | Kd | = | 59900.0 | nM | 4.22 |
| CHEMBL5428405 | — | Kd | = | 64300.0 | nM | 4.19 |
| CHEMBL5567921 | — | Kd | = | 70100.0 | nM | 4.15 |
| CHEMBL5557050 | — | Kd | = | 80600.0 | nM | 4.09 |
| CHEMBL5557824 | — | Kd | = | 86900.0 | nM | 4.06 |
| CHEMBL5398839 | — | Kd | = | 89100.0 | nM | 4.05 |
| CHEMBL5560444 | — | Kd | = | 96300.0 | nM | 4.02 |
| CHEMBL5430291 | — | Kd | = | 130700.0 | nM | - |
| CHEMBL5558025 | — | Kd | = | 103700.0 | nM | - |
| CHEMBL5412740 | — | Kd | - | — | - | |
| CHEMBL5425612 | — | Kd | - | — | - | |
| CHEMBL5403522 | — | Kd | - | — | - | |
| CHEMBL5438701 | — | Kd | - | — | - | |
| CHEMBL5404654 | — | Kd | - | — | - | |
| CHEMBL5408248 | — | Kd | - | — | - | |
| CHEMBL5424388 | — | Kd | - | — | - | |
| CHEMBL165 | RESVERATROL | Kd | = | 125300.0 | nM | - |
| CHEMBL244948 | DAPHNETIN | Kd | = | 336000.0 | nM | - |
| CHEMBL13883 | VANILLIN | Kd | = | 227500.0 | nM | - |
| CHEMBL1797870 | — | Kd | = | 211900.0 | nM | - |
| CHEMBL454533 | NICOTINANILIDE | Kd | = | 336000.0 | nM | - |
| CHEMBL2136039 | — | Kd | = | 297900.0 | nM | - |
| CHEMBL5418790 | — | Kd | - | — | - | |
| CHEMBL5419187 | — | Kd | - | — | - | |
| CHEMBL5409654 | — | Kd | - | — | - | |
| CHEMBL5421402 | — | Kd | - | — | - | |
| CHEMBL5423037 | — | Kd | - | — | - | |
| CHEMBL5437018 | — | Kd | - | — | - | |
| CHEMBL5398320 | — | Kd | - | — | - |