Assay Detail
Functional
CHEMBL5519784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-necroptosis activity against TSZ-induced mouse L929 cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 7.94 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561992 | — | — | 1 | 9.32 |
| CHEMBL5556266 | — | — | 1 | 8.97 |
| CHEMBL5568571 | — | — | 1 | 8.97 |
| CHEMBL5558101 | — | — | 1 | 8.93 |
| CHEMBL5560163 | — | — | 1 | 8.92 |
| CHEMBL5532440 | — | — | 1 | 8.87 |
| CHEMBL5556955 | — | — | 1 | 8.87 |
| CHEMBL5564024 | — | — | 1 | 8.86 |
| CHEMBL5561695 | — | — | 1 | 8.85 |
| CHEMBL5565474 | — | — | 1 | 8.83 |
| CHEMBL5567000 | — | — | 1 | 8.80 |
| CHEMBL5566975 | — | — | 1 | 8.79 |
| CHEMBL5567942 | — | — | 1 | 8.76 |
| CHEMBL5532312 | — | — | 1 | 8.73 |
| CHEMBL5562564 | — | — | 1 | 8.47 |
| CHEMBL5532126 | — | — | 1 | 8.44 |
| CHEMBL5563271 | — | — | 1 | 8.40 |
| CHEMBL5565161 | — | — | 1 | 8.33 |
| CHEMBL5564745 | — | — | 1 | 8.23 |
| CHEMBL5558782 | — | — | 1 | 8.22 |
| CHEMBL5562264 | — | — | 1 | 8.20 |
| CHEMBL5561911 | — | — | 1 | 8.18 |
| CHEMBL5562358 | — | — | 1 | 8.12 |
| CHEMBL5561181 | — | — | 1 | 8.06 |
| CHEMBL5550041 | — | — | 1 | 8.01 |
| CHEMBL5556218 | — | — | 1 | 8.01 |
| CHEMBL5567917 | — | — | 1 | 7.89 |
| CHEMBL5556717 | — | — | 1 | 7.88 |
| CHEMBL5543043 | — | — | 1 | 7.84 |
| CHEMBL5561821 | — | — | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561992 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5556266 | — | EC50 | = | 1.06 | nM | 8.97 |
| CHEMBL5568571 | — | EC50 | = | 1.08 | nM | 8.97 |
| CHEMBL5558101 | — | EC50 | = | 1.17 | nM | 8.93 |
| CHEMBL5560163 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5532440 | — | EC50 | = | 1.35 | nM | 8.87 |
| CHEMBL5556955 | — | EC50 | = | 1.36 | nM | 8.87 |
| CHEMBL5564024 | — | EC50 | = | 1.38 | nM | 8.86 |
| CHEMBL5561695 | — | EC50 | = | 1.42 | nM | 8.85 |
| CHEMBL5565474 | — | EC50 | = | 1.47 | nM | 8.83 |
| CHEMBL5567000 | — | EC50 | = | 1.58 | nM | 8.80 |
| CHEMBL5566975 | — | EC50 | = | 1.62 | nM | 8.79 |
| CHEMBL5567942 | — | EC50 | = | 1.75 | nM | 8.76 |
| CHEMBL5532312 | — | EC50 | = | 1.85 | nM | 8.73 |
| CHEMBL5562564 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5532126 | — | EC50 | = | 3.67 | nM | 8.44 |
| CHEMBL5563271 | — | EC50 | = | 3.95 | nM | 8.40 |
| CHEMBL5565161 | — | EC50 | = | 4.71 | nM | 8.33 |
| CHEMBL5564745 | — | EC50 | = | 5.89 | nM | 8.23 |
| CHEMBL5558782 | — | EC50 | = | 5.99 | nM | 8.22 |
| CHEMBL5562264 | — | EC50 | = | 6.36 | nM | 8.20 |
| CHEMBL5561911 | — | EC50 | = | 6.67 | nM | 8.18 |
| CHEMBL5562358 | — | EC50 | = | 7.61 | nM | 8.12 |
| CHEMBL5561181 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5556218 | — | EC50 | = | 9.79 | nM | 8.01 |
| CHEMBL5550041 | — | EC50 | = | 9.84 | nM | 8.01 |
| CHEMBL5567917 | — | EC50 | = | 12.78 | nM | 7.89 |
| CHEMBL5556717 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL5543043 | — | EC50 | = | 14.31 | nM | 7.84 |
| CHEMBL5561821 | — | EC50 | = | 16.18 | nM | 7.79 |
| CHEMBL5562516 | — | EC50 | = | 20.3 | nM | 7.69 |
| CHEMBL5566463 | — | EC50 | = | 30.19 | nM | 7.52 |
| CHEMBL5567888 | — | EC50 | = | 42.11 | nM | 7.38 |
| CHEMBL5532448 | — | EC50 | = | 45.58 | nM | 7.34 |
| CHEMBL5558270 | — | EC50 | = | 54.42 | nM | 7.26 |
| CHEMBL5563845 | — | EC50 | = | 64.48 | nM | 7.19 |
| CHEMBL5555081 | — | EC50 | = | 113.8 | nM | 6.94 |
| CHEMBL5558020 | — | EC50 | = | 122.7 | nM | 6.91 |
| CHEMBL5568582 | — | EC50 | = | 141.85 | nM | 6.85 |
| CHEMBL5560802 | — | EC50 | = | 310.9 | nM | 6.51 |
| CHEMBL5561817 | — | EC50 | = | 365.8 | nM | 6.44 |
| CHEMBL5567207 | — | EC50 | = | 450.6 | nM | 6.35 |
| CHEMBL5555274 | — | EC50 | = | 659.2 | nM | 6.18 |
| CHEMBL5555219 | — | EC50 | = | 725.8 | nM | 6.14 |
| CHEMBL4071864 | GSK2982772 | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5555294 | — | EC50 | - | — | - | |
| CHEMBL5558543 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5565083 | — | EC50 | - | — | - | |
| CHEMBL5556217 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5562899 | — | EC50 | > | 1000.0 | nM | - |