Assay Detail
Functional
CHEMBL5520103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MNNG/HOS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
91
Total Activities
91
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS-TE85 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent thiazolidin-4-one sulfone derivatives for inhibition of proliferation of osteosarcoma in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 91 | 6.89 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564715 | — | — | 1 | 8.40 |
| CHEMBL5557168 | — | — | 1 | 8.22 |
| CHEMBL5561646 | — | — | 1 | 8.05 |
| CHEMBL5542595 | — | — | 1 | 7.80 |
| CHEMBL5564728 | — | — | 1 | 7.77 |
| CHEMBL5171477 | — | — | 1 | 7.70 |
| CHEMBL5563293 | — | — | 1 | 7.70 |
| CHEMBL5180080 | — | — | 1 | 7.66 |
| CHEMBL5567730 | — | — | 1 | 7.60 |
| CHEMBL5558597 | — | — | 1 | 7.60 |
| CHEMBL5561058 | — | — | 1 | 7.60 |
| CHEMBL5561584 | — | — | 1 | 7.51 |
| CHEMBL5559932 | — | — | 1 | 7.51 |
| CHEMBL5555379 | — | — | 1 | 7.50 |
| CHEMBL5560473 | — | — | 1 | 7.48 |
| CHEMBL5557158 | — | — | 1 | 7.39 |
| CHEMBL5564974 | — | — | 1 | 7.35 |
| CHEMBL5559597 | — | — | 1 | 7.30 |
| CHEMBL5555284 | — | — | 1 | 7.22 |
| CHEMBL5558634 | — | — | 1 | 7.17 |
| CHEMBL5564280 | — | — | 1 | 7.15 |
| CHEMBL5542444 | — | — | 1 | 7.15 |
| CHEMBL5532144 | — | — | 1 | 7.14 |
| CHEMBL5564030 | — | — | 1 | 7.13 |
| CHEMBL5563041 | — | — | 1 | 7.12 |
| CHEMBL5559489 | — | — | 1 | 7.08 |
| CHEMBL5558915 | — | — | 1 | 6.99 |
| CHEMBL5563913 | — | — | 1 | 6.96 |
| CHEMBL5523516 | — | — | 1 | 6.95 |
| CHEMBL5542473 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564715 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5557168 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5561646 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5542595 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5564728 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5171477 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5563293 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5180080 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5567730 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5558597 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5561058 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5561584 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5559932 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5555379 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5560473 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5557158 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5564974 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5559597 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5555284 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5558634 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5564280 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5542444 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5532144 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5564030 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5563041 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5559489 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5558915 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5563913 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5523516 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5542473 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5567788 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5566798 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5559080 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5537063 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5552962 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5555753 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL5560528 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5560906 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5563597 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5560165 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5565679 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL5568462 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5556712 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL5568519 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL5559143 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5560775 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5561607 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL5560191 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL5561686 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL5556005 | — | IC50 | = | 508.0 | nM | 6.29 |