Assay Detail
Functional
CHEMBL5520219
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Antiproliferative activity against human A549 cells incubated for 24 hrs by CCK-8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.45 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566800 | — | — | 1 | 4.78 |
| CHEMBL5561652 | — | — | 1 | 4.71 |
| CHEMBL5555895 | — | — | 1 | 4.58 |
| CHEMBL5560630 | — | — | 1 | 4.30 |
| CHEMBL4297628 | RUXOTEMITIDE | 2.0 | 1 | 4.28 |
| CHEMBL5556816 | — | — | 1 | 4.28 |
| CHEMBL5555708 | — | — | 1 | 4.24 |
| CHEMBL5558457 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566800 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5561652 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL5555895 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL5560630 | — | IC50 | = | 50500.0 | nM | 4.30 |
| CHEMBL4297628 | RUXOTEMITIDE | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL5556816 | — | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL5555708 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL5558457 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 106300.0 | nM | - |