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Compound Detail

CHEMBL5566800

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CC[C@@]1(OC(=O)CCC(=O)NCCCC[C@@H](NC(=O)CCC(=O)O[C@]2(CC)C(=O)OCc3c2cc2n(c3=O)Cc3cc4ccccc4nc3-2)C(=O)NCCOCCOCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(N)=O)C(c2ccccc2)c2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1

Basic Information

ChEMBL ID CHEMBL5566800
Phase Preclinical
Structure Type MOL
InChI Key FVTIYSFAHZEKTH-PDVNYXSQSA-N
8
Targets
9
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

2574.0
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C138H165N25O25
MW 2573.99

Activity Summary

IC50 9 meas. best 5.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A20
CHEMBL613850
IC50 5.41 5.41 3900.0 1
Daudi
CHEMBL614281
IC50 5.09 5.09 8100.0 1
4T1
CHEMBL612589
IC50 5.06 5.06 8800.0 1
HeLa
CHEMBL399
IC50 4.97 4.97 10700.0 1
Ca-Ski
CHEMBL1075403
IC50 4.83 4.83 14700.0 1
A549
CHEMBL392
IC50 4.78 4.78 16500.0 1
Hep 3B2
CHEMBL4296437
IC50 4.76 4.76 17500.0 1
Huh-7
CHEMBL614039
IC50 4.75 4.75 17900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine