Assay Detail
Binding
CHEMBL5520487
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Inhibition of his6-tagged NDM-1 (unknown origin) expressed in Escherichia coli BL21-DE3 incubated for 16 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.14 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561352 | — | — | 1 | 6.54 |
| CHEMBL5542695 | — | — | 1 | 6.11 |
| CHEMBL5560118 | — | — | 1 | 5.92 |
| CHEMBL5542518 | — | — | 1 | 5.57 |
| CHEMBL5560033 | — | — | 1 | 5.51 |
| CHEMBL5558893 | — | — | 1 | 5.11 |
| CHEMBL5562130 | — | — | 1 | 5.10 |
| CHEMBL5555228 | — | — | 1 | 5.08 |
| CHEMBL4639950 | — | — | 1 | 4.89 |
| CHEMBL5558614 | — | — | 1 | 4.89 |
| CHEMBL5560561 | — | — | 1 | 4.70 |
| CHEMBL5558940 | — | — | 1 | 4.57 |
| CHEMBL5568533 | — | — | 1 | 4.54 |
| CHEMBL5559815 | — | — | 1 | 4.28 |
| CHEMBL5543053 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561352 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5542695 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5560118 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5542518 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5560033 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5558893 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5562130 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5555228 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4639950 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5558614 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5560561 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5558940 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5568533 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5559815 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL5543053 | — | IC50 | = | 53000.0 | nM | 4.28 |