Assay Detail
Binding
CHEMBL5520927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to ENPP1 (unknown origin) assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Pyrido[2,3-<i>d</i>]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.60 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556506 | — | — | 1 | 7.48 |
| CHEMBL4284270 | — | — | 1 | 6.51 |
| CHEMBL1783609 | — | — | 1 | 5.80 |
| CHEMBL5561569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556506 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4284270 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL1783609 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5561569 | — | Ki | < | 100.0 | nM | - |