Assay Detail
Binding
CHEMBL5521332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 15 min by HTRF assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent <i>In Vivo</i> Anti-tumor Immune Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.61 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5532575 | — | — | 1 | 8.70 |
| CHEMBL5092744 | — | — | 1 | 8.55 |
| CHEMBL5567941 | — | — | 1 | 8.51 |
| CHEMBL5555899 | — | — | 1 | 8.48 |
| CHEMBL5562864 | — | — | 1 | 8.46 |
| CHEMBL5563757 | — | — | 1 | 8.27 |
| CHEMBL5555222 | — | — | 1 | 8.21 |
| CHEMBL5550000 | — | — | 1 | 8.09 |
| CHEMBL5549774 | — | — | 1 | 8.06 |
| CHEMBL5565356 | — | — | 1 | 7.90 |
| CHEMBL5562590 | — | — | 1 | 7.89 |
| CHEMBL5559742 | — | — | 1 | 7.67 |
| CHEMBL5549836 | — | — | 1 | 7.62 |
| CHEMBL5557352 | — | — | 1 | 7.46 |
| CHEMBL5557637 | — | — | 1 | 7.39 |
| CHEMBL5559658 | — | — | 1 | 7.38 |
| CHEMBL5532011 | — | — | 1 | 7.11 |
| CHEMBL4089730 | — | — | 1 | 7.07 |
| CHEMBL5560388 | — | — | 1 | 7.06 |
| CHEMBL5559438 | — | — | 1 | 6.96 |
| CHEMBL5560372 | — | — | 1 | 6.92 |
| CHEMBL5559838 | — | — | 1 | 6.73 |
| CHEMBL5559404 | — | — | 1 | 6.13 |
| CHEMBL5558595 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5532575 | — | IC50 | = | 2.02 | nM | 8.70 |
| CHEMBL5092744 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5567941 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5555899 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5562864 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5563757 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5555222 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5550000 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5549774 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5565356 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5562590 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5559742 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL5549836 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL5557352 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL5557637 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL5559658 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL5532011 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL4089730 | — | IC50 | = | 85.3 | nM | 7.07 |
| CHEMBL5560388 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL5559438 | — | IC50 | = | 108.9 | nM | 6.96 |
| CHEMBL5560372 | — | IC50 | = | 121.1 | nM | 6.92 |
| CHEMBL5559838 | — | IC50 | = | 187.5 | nM | 6.73 |
| CHEMBL5559404 | — | IC50 | = | 745.7 | nM | 6.13 |
| CHEMBL5558595 | — | IC50 | = | 785.6 | nM | 6.11 |