Assay Detail
Binding
CHEMBL5521389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAT2a (unknown origin) using methionine and ATP as substrate assessed as reduction in S-adenosyl-L-methionine formation incubated for 300 mins by RapidFire-Mass Spectrometry analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
S-adenosylmethionine synthase isoform type-2 (CHEMBL3313835) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.61 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573938 | — | — | 1 | 9.40 |
| CHEMBL5561157 | — | — | 1 | 9.30 |
| CHEMBL5560496 | — | — | 1 | 9.10 |
| CHEMBL5562574 | — | — | 1 | 8.00 |
| CHEMBL5558360 | — | — | 1 | 7.90 |
| CHEMBL5560583 | — | — | 1 | 7.20 |
| CHEMBL5563282 | — | — | 1 | 6.80 |
| CHEMBL5560046 | — | — | 1 | 6.60 |
| CHEMBL5556711 | — | — | 1 | 6.10 |
| CHEMBL5557833 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573938 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL5561157 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5560496 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL5562574 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5558360 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5560583 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5563282 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5560046 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5556711 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5557833 | — | IC50 | = | 1995.26 | nM | 5.70 |