Assay Detail
Binding
CHEMBL5521817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Met (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.80 | 9.40 |
| Ki | 1 | 6.47 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.89 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.10 |
| CHEMBL2103882 | TIVANTINIB | 3.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2103882 | TIVANTINIB | Ki | = | 335.0 | nM | 6.47 |