Assay Detail
Binding
CHEMBL5521824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as chromogenic substrate preincubated for 30 mins followed by substrate addition by absorbance based analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.61 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558547 | — | — | 1 | 6.91 |
| CHEMBL5568169 | — | — | 1 | 6.02 |
| CHEMBL5559738 | — | — | 1 | 5.96 |
| CHEMBL5555448 | — | — | 1 | 5.91 |
| CHEMBL5560415 | — | — | 1 | 5.87 |
| CHEMBL5560759 | — | — | 1 | 5.58 |
| CHEMBL5561725 | — | — | 1 | 5.50 |
| CHEMBL5559988 | — | — | 1 | 5.37 |
| CHEMBL5564865 | — | — | 1 | 5.06 |
| CHEMBL5562350 | — | — | 1 | 5.05 |
| CHEMBL5557087 | — | — | 1 | 5.02 |
| CHEMBL5556134 | — | — | 1 | 5.02 |
| CHEMBL5557551 | — | — | 1 | - |
| CHEMBL5558228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558547 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5568169 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL5559738 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5555448 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5560415 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5560759 | — | IC50 | = | 2646.0 | nM | 5.58 |
| CHEMBL5561725 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5559988 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL5564865 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5562350 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL5557087 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL5556134 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL5557551 | — | IC50 | - | — | - | |
| CHEMBL5558228 | — | IC50 | - | — | - |