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Assay Detail

CHEMBL5521862

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against DENV-4 H241 infected in african green monkey Vero cells incubated for 24 hrs measured after 3 days post infection by RT-PCR analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 4
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 4 (CHEMBL613728)
Type ORGANISM
Organism dengue virus type 4

Publication

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
Kesteleyn B, Bonfanti JF, Bardiot D, De Boeck B, Goethals O, Kaptein SJF, Stoops B, Coesemans E, Fortin J, Muller P, Doublet F, Carlens G, Koukni M, Smets W, Raboisson P, Chaltin P, Simmen K, Loock MV, Neyts J, Marchand A, Jonckers THM.
J Med Chem (2024) 67 : 4063 -4082
PubMed 38482827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 6.89 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5562312 1 7.96
CHEMBL5314530 MOSNODENVIR 2.0 1 7.96
CHEMBL3905772 1 7.96
CHEMBL5555759 1 7.82
CHEMBL3923294 1 7.36
CHEMBL5559307 1 7.28
CHEMBL5566989 1 7.15
CHEMBL3905304 1 7.08
CHEMBL5566158 1 7.02
CHEMBL5559826 1 7.00
CHEMBL5542636 1 6.96
CHEMBL5563912 1 6.96
CHEMBL5556494 1 6.96
CHEMBL5558438 1 6.77
CHEMBL5555341 1 6.64
CHEMBL5555250 1 6.54
CHEMBL5566578 1 6.12
CHEMBL5563352 1 5.75
CHEMBL4214447 1 5.58
CHEMBL5542213 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5562312 EC50 = 11.0 nM 7.96
CHEMBL5314530 MOSNODENVIR EC50 = 11.0 nM 7.96
CHEMBL3905772 EC50 = 11.0 nM 7.96
CHEMBL5555759 EC50 = 15.0 nM 7.82
CHEMBL3923294 EC50 = 44.0 nM 7.36
CHEMBL5559307 EC50 = 53.0 nM 7.28
CHEMBL5566989 EC50 = 71.0 nM 7.15
CHEMBL3905304 EC50 = 83.0 nM 7.08
CHEMBL5566158 EC50 = 95.0 nM 7.02
CHEMBL5559826 EC50 = 100.0 nM 7.00
CHEMBL5542636 EC50 = 110.0 nM 6.96
CHEMBL5563912 EC50 = 110.0 nM 6.96
CHEMBL5556494 EC50 = 110.0 nM 6.96
CHEMBL5558438 EC50 = 170.0 nM 6.77
CHEMBL5555341 EC50 = 230.0 nM 6.64
CHEMBL5555250 EC50 = 290.0 nM 6.54
CHEMBL5566578 EC50 = 760.0 nM 6.12
CHEMBL5563352 EC50 = 1800.0 nM 5.75
CHEMBL4214447 EC50 = 2600.0 nM 5.58
CHEMBL5542213 EC50 = 14000.0 nM 4.85