Assay Detail
Toxicity
CHEMBL5521931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCM460 cells incubated for 72 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | NCM460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
DNA Interaction and Cleavage Modes of Anthraquinone-Fused Enediynes: A Study on Tiancimycins, Yangpumicins, and Their Semisynthetic Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.77 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557975 | — | — | 1 | 10.15 |
| CHEMBL4466320 | — | — | 1 | 10.00 |
| CHEMBL4636420 | — | — | 1 | 9.70 |
| CHEMBL4472466 | — | — | 1 | 9.70 |
| CHEMBL5557688 | — | — | 1 | 9.40 |
| CHEMBL5555325 | — | — | 1 | 9.22 |
| CHEMBL5559818 | — | — | 1 | 8.55 |
| CHEMBL5560250 | — | — | 1 | 8.48 |
| CHEMBL5557704 | — | — | 1 | 8.22 |
| CHEMBL5557402 | — | — | 1 | 6.64 |
| CHEMBL5567770 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557975 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4466320 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4636420 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4472466 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5557688 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5555325 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5559818 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5560250 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5557704 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5557402 | — | IC50 | = | 226.6 | nM | 6.64 |
| CHEMBL5567770 | — | IC50 | = | 381.8 | nM | 6.42 |