Assay Detail
Binding
CHEMBL5522136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D catalytic domain (T86 to S413 residues) expressed in Escherichia coli BL21 (DE3) using [3H]-cAMP/cGMP as substrate incubated for 10 mins by MicroBeta scintillation proximity assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.82 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562344 | — | — | 1 | 6.77 |
| CHEMBL5560091 | — | — | 1 | 6.54 |
| CHEMBL1991200 | — | — | 1 | 5.94 |
| CHEMBL484785 | CRISABOROLE | 4.0 | 1 | 5.94 |
| CHEMBL464374 | — | — | 1 | 5.89 |
| CHEMBL5561298 | — | — | 1 | 5.89 |
| CHEMBL5562065 | — | — | 1 | 5.55 |
| CHEMBL1971313 | — | — | 1 | 5.49 |
| CHEMBL5549963 | — | — | 1 | 5.26 |
| CHEMBL5563938 | — | — | 1 | 4.90 |
| CHEMBL1977166 | — | — | 1 | - |
| CHEMBL5563004 | — | — | 1 | - |
| CHEMBL5562424 | — | — | 1 | - |
| CHEMBL5556061 | — | — | 1 | - |
| CHEMBL5561279 | — | — | 1 | - |
| CHEMBL5555586 | — | — | 1 | - |
| CHEMBL5560239 | — | — | 1 | - |
| CHEMBL2261308 | — | — | 1 | - |
| CHEMBL5560387 | — | — | 1 | - |
| CHEMBL5562969 | — | — | 1 | - |
| CHEMBL5560423 | — | — | 1 | - |
| CHEMBL5557916 | — | — | 1 | - |
| CHEMBL5566327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562344 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5560091 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1991200 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL484785 | CRISABOROLE | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL464374 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5561298 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5562065 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL1971313 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL5549963 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL5563938 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL1977166 | — | IC50 | - | — | - | |
| CHEMBL5563004 | — | IC50 | - | — | - | |
| CHEMBL5562424 | — | IC50 | - | — | - | |
| CHEMBL5556061 | — | IC50 | - | — | - | |
| CHEMBL5561279 | — | IC50 | - | — | - | |
| CHEMBL5555586 | — | IC50 | - | — | - | |
| CHEMBL5560239 | — | IC50 | - | — | - | |
| CHEMBL2261308 | — | IC50 | - | — | - | |
| CHEMBL5560387 | — | IC50 | - | — | - | |
| CHEMBL5562969 | — | IC50 | - | — | - | |
| CHEMBL5560423 | — | IC50 | - | — | - | |
| CHEMBL5557916 | — | IC50 | - | — | - | |
| CHEMBL5566327 | — | IC50 | - | — | - |