Compound Detail
CHEMBL5562065
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Basic Information
| ChEMBL ID | CHEMBL5562065 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NNEVIYNTQNMGOG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
458.5
MW (Da)
3.99
ALogP
8
HBA
0
HBD
89.5
PSA (Ų)
0.49
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 5.55 | 5.55 | 2820.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 2820.0 | nM | 5.55 | Inhibition of human PDE4D catalytic domain (T86 to S413 residues) expressed in E... | 38489246 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38489246 | 10.1021/acs.jmedchem.3c02424 | 3',5'-cyclic-AMP phosphodiesterase 4D | 3 |
Data from ChEMBL 36 via Core Engine