Assay Detail
ADMET
CHEMBL5522600
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Inhibition of human recombinant CYP1B1 using 7-ethoxyresorufin as substrate preincubated with enzyme for 5 mins followed by fluorescent substrate and NADPH addition and measured after 35 mins by EROD assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.26 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560596 | — | — | 1 | 10.70 |
| CHEMBL5557701 | — | — | 1 | 10.70 |
| CHEMBL5561280 | — | — | 1 | 9.82 |
| CHEMBL5561334 | — | — | 1 | 9.62 |
| CHEMBL5555246 | — | — | 1 | 9.31 |
| CHEMBL5560939 | — | — | 1 | 8.77 |
| CHEMBL5560888 | — | — | 1 | 8.61 |
| CHEMBL5563177 | — | — | 1 | 8.51 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.29 |
| CHEMBL5565554 | — | — | 1 | - |
| CHEMBL5568160 | — | — | 1 | - |
| CHEMBL5560837 | — | — | 1 | - |
| CHEMBL5566974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560596 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5557701 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5561280 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5561334 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5555246 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5560939 | — | IC50 | = | 1.69 | nM | 8.77 |
| CHEMBL5560888 | — | IC50 | = | 2.48 | nM | 8.61 |
| CHEMBL5563177 | — | IC50 | = | 3.07 | nM | 8.51 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 50.84 | nM | 7.29 |
| CHEMBL5565554 | — | IC50 | = | 1.68 | 10^-4nM | - |
| CHEMBL5568160 | — | IC50 | = | 4.14e-05 | nM | - |
| CHEMBL5560837 | — | IC50 | = | 7.47 | 10^-4nM | - |
| CHEMBL5566974 | — | IC50 | = | 2.05 | 10^-4nM | - |