Assay Detail
ADMET
CHEMBL5522601
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Inhibition of human recombinant CYP1A1 using 7-ethoxyresorufin as substrate preincubated with enzyme for 5 mins followed by fluorescent substrate and NADPH addition and measured after 15 mins by EROD assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.45 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566974 | — | — | 1 | 8.79 |
| CHEMBL5557701 | — | — | 1 | 8.24 |
| CHEMBL5560596 | — | — | 1 | 7.91 |
| CHEMBL5560837 | — | — | 1 | 7.58 |
| CHEMBL5565554 | — | — | 1 | 7.56 |
| CHEMBL5563177 | — | — | 1 | 7.55 |
| CHEMBL5561280 | — | — | 1 | 7.48 |
| CHEMBL5561334 | — | — | 1 | 7.43 |
| CHEMBL5568160 | — | — | 1 | 7.07 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.06 |
| CHEMBL5555246 | — | — | 1 | 6.99 |
| CHEMBL5560888 | — | — | 1 | 6.61 |
| CHEMBL5560939 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566974 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL5557701 | — | IC50 | = | 5.74 | nM | 8.24 |
| CHEMBL5560596 | — | IC50 | = | 12.35 | nM | 7.91 |
| CHEMBL5560837 | — | IC50 | = | 26.48 | nM | 7.58 |
| CHEMBL5565554 | — | IC50 | = | 27.41 | nM | 7.56 |
| CHEMBL5563177 | — | IC50 | = | 28.13 | nM | 7.55 |
| CHEMBL5561280 | — | IC50 | = | 33.16 | nM | 7.48 |
| CHEMBL5561334 | — | IC50 | = | 36.69 | nM | 7.43 |
| CHEMBL5568160 | — | IC50 | = | 85.83 | nM | 7.07 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 86.67 | nM | 7.06 |
| CHEMBL5555246 | — | IC50 | = | 103.58 | nM | 6.99 |
| CHEMBL5560888 | — | IC50 | = | 247.8 | nM | 6.61 |
| CHEMBL5560939 | — | IC50 | = | 262.8 | nM | 6.58 |