Assay Detail
Functional
CHEMBL5522640
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Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.78 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558402 | — | — | 1 | 5.85 |
| CHEMBL2105738 | GALETERONE | 3.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558402 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2105738 | GALETERONE | IC50 | = | 2000.0 | nM | 5.70 |