Assay Detail
Functional
CHEMBL5522786
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Antiproliferative activity against AR positive human LNCaP cells assessed inhibition of cell growth measured after 4 days by CellTiter-Glo Luminescent cell viability assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.47 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562164 | — | — | 1 | 8.80 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | 1.0 | 1 | 6.91 |
| CHEMBL4785363 | INOBRODIB | 1.0 | 1 | 6.38 |
| CHEMBL4076748 | — | — | 1 | 5.16 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562164 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4785363 | INOBRODIB | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL4076748 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 8000.0 | nM | 5.10 |