Assay Detail
Binding
CHEMBL5523066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NIK (unknown origin) incubated 30 to 60 mins by ADP-Glo Kinase assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 7.91 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562073 | — | — | 1 | 8.90 |
| CHEMBL3187788 | — | — | 1 | 8.57 |
| CHEMBL5556543 | — | — | 1 | 8.54 |
| CHEMBL5562819 | — | — | 1 | 8.42 |
| CHEMBL5558670 | — | — | 1 | 8.36 |
| CHEMBL5555483 | — | — | 1 | 8.35 |
| CHEMBL5566214 | — | — | 1 | 8.34 |
| CHEMBL5558913 | — | — | 1 | 8.32 |
| CHEMBL5564890 | — | — | 1 | 8.32 |
| CHEMBL5523606 | — | — | 1 | 8.30 |
| CHEMBL5558099 | — | — | 1 | 8.29 |
| CHEMBL5567931 | — | — | 1 | 8.27 |
| CHEMBL5556361 | — | — | 1 | 8.27 |
| CHEMBL5542106 | — | — | 1 | 8.24 |
| CHEMBL5562730 | — | — | 1 | 8.23 |
| CHEMBL5558790 | — | — | 1 | 8.21 |
| CHEMBL5532359 | — | — | 1 | 8.19 |
| CHEMBL5556126 | — | — | 1 | 8.17 |
| CHEMBL5555309 | — | — | 1 | 8.16 |
| CHEMBL5559971 | — | — | 1 | 8.16 |
| CHEMBL5559954 | — | — | 1 | 8.13 |
| CHEMBL5542501 | — | — | 1 | 8.11 |
| CHEMBL5555681 | — | — | 1 | 8.08 |
| CHEMBL5562681 | — | — | 1 | 8.04 |
| CHEMBL5559666 | — | — | 1 | 8.03 |
| CHEMBL5542810 | — | — | 1 | 8.01 |
| CHEMBL5561281 | — | — | 1 | 7.97 |
| CHEMBL5559944 | — | — | 1 | 7.95 |
| CHEMBL5558195 | — | — | 1 | 7.95 |
| CHEMBL5557496 | — | — | 1 | 7.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562073 | — | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL3187788 | — | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL5556543 | — | IC50 | = | 2.85 | nM | 8.54 |
| CHEMBL5562819 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL5558670 | — | IC50 | = | 4.33 | nM | 8.36 |
| CHEMBL5555483 | — | IC50 | = | 4.43 | nM | 8.35 |
| CHEMBL5566214 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5558913 | — | IC50 | = | 4.73 | nM | 8.32 |
| CHEMBL5564890 | — | IC50 | = | 4.76 | nM | 8.32 |
| CHEMBL5523606 | — | IC50 | = | 5.01 | nM | 8.30 |
| CHEMBL5558099 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5567931 | — | IC50 | = | 5.39 | nM | 8.27 |
| CHEMBL5556361 | — | IC50 | = | 5.35 | nM | 8.27 |
| CHEMBL5542106 | — | IC50 | = | 5.77 | nM | 8.24 |
| CHEMBL5562730 | — | IC50 | = | 5.93 | nM | 8.23 |
| CHEMBL5558790 | — | IC50 | = | 6.17 | nM | 8.21 |
| CHEMBL5532359 | — | IC50 | = | 6.46 | nM | 8.19 |
| CHEMBL5556126 | — | IC50 | = | 6.74 | nM | 8.17 |
| CHEMBL5555309 | — | IC50 | = | 6.99 | nM | 8.16 |
| CHEMBL5559971 | — | IC50 | = | 6.96 | nM | 8.16 |
| CHEMBL5559954 | — | IC50 | = | 7.44 | nM | 8.13 |
| CHEMBL5542501 | — | IC50 | = | 7.76 | nM | 8.11 |
| CHEMBL5555681 | — | IC50 | = | 8.34 | nM | 8.08 |
| CHEMBL5562681 | — | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL5559666 | — | IC50 | = | 9.36 | nM | 8.03 |
| CHEMBL5542810 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5561281 | — | IC50 | = | 10.67 | nM | 7.97 |
| CHEMBL5559944 | — | IC50 | = | 11.28 | nM | 7.95 |
| CHEMBL5558195 | — | IC50 | = | 11.32 | nM | 7.95 |
| CHEMBL5557496 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5568101 | — | IC50 | = | 11.52 | nM | 7.94 |
| CHEMBL5556122 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5560481 | — | IC50 | = | 14.12 | nM | 7.85 |
| CHEMBL5559317 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL5560584 | — | IC50 | = | 14.78 | nM | 7.83 |
| CHEMBL5559279 | — | IC50 | = | 15.36 | nM | 7.81 |
| CHEMBL5562541 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5532194 | — | IC50 | = | 16.47 | nM | 7.78 |
| CHEMBL5560312 | — | IC50 | = | 22.06 | nM | 7.66 |
| CHEMBL5568418 | — | IC50 | = | 22.66 | nM | 7.64 |
| CHEMBL5555896 | — | IC50 | = | 24.59 | nM | 7.61 |
| CHEMBL5563771 | — | IC50 | = | 29.09 | nM | 7.54 |
| CHEMBL5555322 | — | IC50 | = | 34.17 | nM | 7.47 |
| CHEMBL5548835 | — | IC50 | = | 58.44 | nM | 7.23 |
| CHEMBL5560676 | — | IC50 | = | 70.81 | nM | 7.15 |
| CHEMBL5566316 | — | IC50 | = | 89.36 | nM | 7.05 |
| CHEMBL5556980 | — | IC50 | = | 131.2 | nM | 6.88 |
| CHEMBL5532009 | — | IC50 | = | 208.37 | nM | 6.68 |
| CHEMBL5532579 | — | IC50 | = | 341.28 | nM | 6.47 |
| CHEMBL5561190 | — | IC50 | = | 432.61 | nM | 6.36 |