Assay Detail
Binding
CHEMBL5524064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of CFTR F508del mutant (unknown origin) expressed in NIH3T3 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cystic fibrosis transmembrane conductance regulator (CHEMBL4051) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR): Structure, classification, and mechanisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.53 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544914 | TEZACAFTOR | 4.0 | 1 | 5.96 |
| CHEMBL1257047 | — | — | 1 | 5.48 |
| CHEMBL4176184 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544914 | TEZACAFTOR | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1257047 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4176184 | — | EC50 | = | 7000.0 | nM | 5.16 |