Assay Detail
Functional
CHEMBL5524121
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Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium mobilization by Fluo-4 AM dye based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.27 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3588871 | — | — | 1 | 6.72 |
| CHEMBL5558209 | — | — | 1 | 6.68 |
| CHEMBL5280317 | — | — | 1 | 6.44 |
| CHEMBL5284903 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3588871 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5558209 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5280317 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5284903 | — | EC50 | = | 5600.0 | nM | 5.25 |