Assay Detail
Functional
CHEMBL5524224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.69 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 4.86 |
| CHEMBL5565656 | — | — | 1 | 4.81 |
| CHEMBL5563696 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL5565656 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5563696 | — | IC50 | = | 39900.0 | nM | 4.40 |