Assay Detail
Binding
CHEMBL5524266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His6-tagged ASPH (R315 to I758 residues) expressed in Escherichia coli BL21 (DE3) using hFX-CP as substrate preincubated for 15 mins followed by substrate and 2-OG addition measured after 15 mins by SPE-MS analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aspartyl/asparaginyl beta-hydroxylase (CHEMBL4680030) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pIC50 | 2 | - | - |
| IC50 | 1 | 4.97 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557372 | — | — | 1 | 4.97 |
| CHEMBL1230640 | — | — | 1 | - |
| CHEMBL5542589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557372 | — | IC50 | = | 10715.19 | nM | 4.97 |
| CHEMBL1230640 | — | pIC50 | - | — | - | |
| CHEMBL5542589 | — | pIC50 | - | — | - |