Assay Detail
Functional
CHEMBL5524649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.70 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.60 |
| CHEMBL5561700 | — | — | 1 | 5.32 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.29 |
| CHEMBL5562199 | — | — | 1 | 4.59 |
| CHEMBL5558069 | — | — | 1 | - |
| CHEMBL5532578 | — | — | 1 | - |
| CHEMBL5558625 | — | — | 1 | - |
| CHEMBL5562342 | — | — | 1 | - |
| CHEMBL5561303 | — | — | 1 | - |
| CHEMBL5532591 | — | — | 1 | - |
| CHEMBL5566103 | — | — | 1 | - |
| CHEMBL5567935 | — | — | 1 | - |
| CHEMBL600662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5561700 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL5562199 | — | IC50 | = | 25850.0 | nM | 4.59 |
| CHEMBL5558069 | — | IC50 | = | 230140.0 | nM | - |
| CHEMBL5532578 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5558625 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5562342 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5561303 | — | IC50 | = | 156770.0 | nM | - |
| CHEMBL5532591 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5566103 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5567935 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL600662 | — | IC50 | > | 300000.0 | nM | - |