Assay Detail
Functional
CHEMBL5524871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferation activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK8 assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.70 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5542292 | — | — | 1 | 8.85 |
| CHEMBL5562453 | — | — | 1 | 8.64 |
| CHEMBL5561696 | — | — | 1 | 8.57 |
| CHEMBL5562316 | — | — | 1 | 8.51 |
| CHEMBL5565789 | — | — | 1 | 8.43 |
| CHEMBL5563544 | — | — | 1 | 8.43 |
| CHEMBL5542497 | — | — | 1 | 8.41 |
| CHEMBL5568350 | — | — | 1 | 8.32 |
| CHEMBL5542952 | — | — | 1 | 8.16 |
| CHEMBL5562530 | — | — | 1 | 8.09 |
| CHEMBL5314555 | LIRAFUGRATINIB | 2.0 | 1 | 8.05 |
| CHEMBL5563950 | — | — | 1 | 8.00 |
| CHEMBL5558468 | — | — | 1 | 7.89 |
| CHEMBL5565979 | — | — | 1 | 7.87 |
| CHEMBL5558763 | — | — | 1 | 7.85 |
| CHEMBL5561320 | — | — | 1 | 7.81 |
| CHEMBL5556378 | — | — | 1 | 7.81 |
| CHEMBL5557970 | — | — | 1 | 7.80 |
| CHEMBL5560352 | — | — | 1 | 7.79 |
| CHEMBL5557549 | — | — | 1 | 7.77 |
| CHEMBL5560341 | — | — | 1 | 7.39 |
| CHEMBL5567016 | — | — | 1 | 7.30 |
| CHEMBL5559012 | — | — | 1 | 7.27 |
| CHEMBL5561318 | — | — | 1 | 7.24 |
| CHEMBL5564910 | — | — | 1 | 7.23 |
| CHEMBL5558304 | — | — | 1 | 7.06 |
| CHEMBL5564864 | — | — | 1 | 6.69 |
| CHEMBL5566546 | — | — | 1 | 6.63 |
| CHEMBL5568507 | — | — | 1 | 6.56 |
| CHEMBL5542495 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5542292 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5562453 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5561696 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5562316 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5565789 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5563544 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5542497 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5568350 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5542952 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5562530 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5314555 | LIRAFUGRATINIB | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL5563950 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5558468 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5565979 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL5558763 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5561320 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5556378 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5557970 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5560352 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5557549 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL5560341 | — | IC50 | = | 40.6 | nM | 7.39 |
| CHEMBL5567016 | — | IC50 | = | 49.7 | nM | 7.30 |
| CHEMBL5559012 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL5561318 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL5564910 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5558304 | — | IC50 | = | 87.3 | nM | 7.06 |
| CHEMBL5564864 | — | IC50 | = | 202.2 | nM | 6.69 |
| CHEMBL5566546 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL5568507 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL5542495 | — | IC50 | = | 418.5 | nM | 6.38 |
| CHEMBL5564829 | — | IC50 | = | 923.3 | nM | 6.04 |
| CHEMBL5564803 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5562573 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5568468 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5563529 | — | IC50 | > | 1000.0 | nM | - |