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Assay Detail

CHEMBL5526165

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human AMY3R complex of CTR/RAMP3 expressed in Baby hamster kidney cells incubated for 3 hrs followed by medium replacement without compound measured after 30 mins by luciferase reporter assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Kidney
Cell Type Baby hamster kidney cell
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2111190)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Dahl K, Raun K, Hansen JL, Poulsen C, de la Cour CD, Clausen TR, Hansen AMK, John LM, Plesner A, Sun G, Schlein M, Skyggebjerg RB, Kruse T.
J Med Chem (2024) 67 : 11688 -11700
PubMed 38960379 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 9.56 10.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5567107 1 10.33
CHEMBL5560328 1 9.82
CHEMBL5567446 1 9.79
CHEMBL5567377 1 9.75
CHEMBL5563010 1 9.74
CHEMBL5568431 1 9.73
CHEMBL5568414 1 9.70
CHEMBL5568471 1 9.66
CHEMBL5568545 1 9.66
CHEMBL5554990 1 9.65
CHEMBL5560790 1 9.57
CHEMBL5566453 1 9.51
CHEMBL5565993 1 9.50
CHEMBL5556440 1 9.47
CHEMBL5560524 1 9.46
CHEMBL5566450 1 9.45
CHEMBL5561117 1 9.44
CHEMBL5555676 1 9.41
CHEMBL5568143 1 9.37
CHEMBL5532322 1 8.97
CHEMBL5531967 1 8.81
CHEMBL2103758 PRAMLINTIDE 4.0 1 -
CHEMBL3989767 CALCITONIN SALMON 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5567107 EC50 = 0.047 nM 10.33
CHEMBL5560328 EC50 = 0.151 nM 9.82
CHEMBL5567446 EC50 = 0.161 nM 9.79
CHEMBL5567377 EC50 = 0.177 nM 9.75
CHEMBL5563010 EC50 = 0.18 nM 9.74
CHEMBL5568431 EC50 = 0.186 nM 9.73
CHEMBL5568414 EC50 = 0.2 nM 9.70
CHEMBL5568471 EC50 = 0.219 nM 9.66
CHEMBL5568545 EC50 = 0.217 nM 9.66
CHEMBL5554990 EC50 = 0.222 nM 9.65
CHEMBL5560790 EC50 = 0.267 nM 9.57
CHEMBL5566453 EC50 = 0.31 nM 9.51
CHEMBL5565993 EC50 = 0.319 nM 9.50
CHEMBL5556440 EC50 = 0.34 nM 9.47
CHEMBL5560524 EC50 = 0.35 nM 9.46
CHEMBL5566450 EC50 = 0.352 nM 9.45
CHEMBL5561117 EC50 = 0.364 nM 9.44
CHEMBL5555676 EC50 = 0.39 nM 9.41
CHEMBL5568143 EC50 = 0.432 nM 9.37
CHEMBL5532322 EC50 = 1.061 nM 8.97
CHEMBL5531967 EC50 = 1.535 nM 8.81
CHEMBL2103758 PRAMLINTIDE EC50 = 0.005 nM -
CHEMBL3989767 CALCITONIN SALMON EC50 = 0.0016 nM -