Assay Detail
Functional
CHEMBL5526168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat AMY3R complex of CTR/RAMP3 expressed in Baby hamster kidney cells incubated for 3 hrs by cAMP assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Cell Type | Baby hamster kidney cell |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2109235) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.14 | 9.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567377 | — | — | 1 | 9.58 |
| CHEMBL5563010 | — | — | 1 | 9.33 |
| CHEMBL5566453 | — | — | 1 | 9.22 |
| CHEMBL5567446 | — | — | 1 | 9.19 |
| CHEMBL5561117 | — | — | 1 | 9.12 |
| CHEMBL5560328 | — | — | 1 | 9.03 |
| CHEMBL5568431 | — | — | 1 | 8.89 |
| CHEMBL5568143 | — | — | 1 | 8.75 |
| CHEMBL2103758 | PRAMLINTIDE | 4.0 | 1 | - |
| CHEMBL3989767 | CALCITONIN SALMON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567377 | — | EC50 | = | 0.262 | nM | 9.58 |
| CHEMBL5563010 | — | EC50 | = | 0.463 | nM | 9.33 |
| CHEMBL5566453 | — | EC50 | = | 0.599 | nM | 9.22 |
| CHEMBL5567446 | — | EC50 | = | 0.643 | nM | 9.19 |
| CHEMBL5561117 | — | EC50 | = | 0.754 | nM | 9.12 |
| CHEMBL5560328 | — | EC50 | = | 0.926 | nM | 9.03 |
| CHEMBL5568431 | — | EC50 | = | 1.288 | nM | 8.89 |
| CHEMBL5568143 | — | EC50 | = | 1.788 | nM | 8.75 |
| CHEMBL2103758 | PRAMLINTIDE | EC50 | = | 0.004 | nM | - |
| CHEMBL3989767 | CALCITONIN SALMON | EC50 | = | 0.00052 | nM | - |