Assay Detail
Functional
CHEMBL5526195
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AM2R complex of CRLR/RAMP3 transduced in human HeLa cells by cAMP assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Adrenomedullin receptor, AM2; CALCRL/RAMP3 (CHEMBL2111191) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 2 | 6.48 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103758 | PRAMLINTIDE | 4.0 | 1 | 6.83 |
| CHEMBL4802169 | CAGRILINTIDE | 3.0 | 1 | 6.12 |
| CHEMBL5567377 | — | — | 1 | - |
| CHEMBL3989767 | CALCITONIN SALMON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103758 | PRAMLINTIDE | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL4802169 | CAGRILINTIDE | EC50 | = | 758.58 | nM | 6.12 |
| CHEMBL5567377 | — | Activity | - | — | - | |
| CHEMBL3989767 | CALCITONIN SALMON | Activity | - | — | - |