Assay Detail
Functional
CHEMBL5526288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring TPR-MET fusion protein incubated for 72 hrs by CellTiter-Glo reagent based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective c-Met Degraders for Hepatocellular Carcinoma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.25 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402762 | TEPOTINIB | 4.0 | 1 | 8.28 |
| CHEMBL5558415 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402762 | TEPOTINIB | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5558415 | — | IC50 | = | 6.2 | nM | 8.21 |