Assay Detail
Functional
CHEMBL5526290
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Antiproliferative activity against mouse BaF3 cells harboring TPR-MET Y1230H mutant fusion protein incubated for 72 hrs by CellTiter-Glo reagent based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective c-Met Degraders for Hepatocellular Carcinoma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.08 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558415 | — | — | 1 | 6.42 |
| CHEMBL3402762 | TEPOTINIB | 4.0 | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558415 | — | IC50 | = | 378.5 | nM | 6.42 |
| CHEMBL3402762 | TEPOTINIB | IC50 | = | 1835.0 | nM | 5.74 |