Assay Detail
Binding
CHEMBL5527104
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Binding affinity to D1 receptor (unknown origin) assessed as inhibition constant
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.04 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1672309 | — | — | 1 | 9.27 |
| CHEMBL1672312 | — | — | 1 | 9.08 |
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 8.92 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 8.29 |
| CHEMBL2334891 | — | — | 1 | 8.26 |
| CHEMBL1962947 | — | — | 1 | 8.24 |
| CHEMBL3697617 | TAVAPADON | 3.0 | 1 | 8.07 |
| CHEMBL5563974 | — | — | 1 | 8.06 |
| CHEMBL4633772 | — | — | 1 | 7.24 |
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 7.21 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.92 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 6.91 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 6.75 |
| CHEMBL4637246 | — | — | 1 | 6.52 |
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 6.26 |
| CHEMBL27559 | — | — | 1 | 6.16 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.13 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 5.93 |
| CHEMBL405345 | — | — | 1 | 5.77 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.63 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 5.47 |
| CHEMBL2425376 | — | — | 1 | 5.42 |
| CHEMBL1201087 | CABERGOLINE | 4.0 | 1 | 5.42 |
| CHEMBL255229 | — | — | 1 | - |
| CHEMBL403550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1672309 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL1672312 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL298406 | ECOPIPAM | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2334891 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1962947 | — | Ki | = | 5.77 | nM | 8.24 |
| CHEMBL3697617 | TAVAPADON | Ki | = | 8.54 | nM | 8.07 |
| CHEMBL5563974 | — | Ki | = | 8.75 | nM | 8.06 |
| CHEMBL4633772 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL157138 | LISURIDE | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL487182 | TETRAHYDROPALMATINE | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL4637246 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL1621 | PALIPERIDONE | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL27559 | — | Ki | = | 699.0 | nM | 6.16 |
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 733.0 | nM | 6.13 |
| CHEMBL531 | PERGOLIDE | Ki | = | 1163.0 | nM | 5.93 |
| CHEMBL405345 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL59 | DOPAMINE | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 3418.0 | nM | 5.47 |
| CHEMBL2425376 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL1201087 | CABERGOLINE | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL255229 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL403550 | — | Ki | > | 20000.0 | nM | - |