Assay Detail
Binding
CHEMBL5527116
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Binding affinity to alpha2B adrenergic receptor (unknown origin) assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural Product-Inspired Dopamine Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1621 | PALIPERIDONE | 4.0 | 1 | 8.40 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 1 | 7.09 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1621 | PALIPERIDONE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 81.6 | nM | 7.09 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 480.0 | nM | 6.32 |